Actaea racemosa

What is Actaea racemosa?

Actaea racemosa, also known as Black cohosh, is a perennial herb native to North America. It is traditionally used to aid hot flushes and other menopausal symptoms. Extracts of Actaea racemosa are made from the root and underground stems (rhizomes) and then formulated into a product.

The history of Actaea racemosa use

Historically, Actaea racemosa was used by North American Indians for a variety of ailments.  In the 19th century America, it gained popularity as a home remedy for a variety of ailments, as a diuretic, and to bring on menstruation. Actaea racemosa also became a popular herbal remedy among European women in the 1950’s.

Today, Actaea racemosa is widely used by women all around the world who are looking for a natural way to address hot flushes and other symptoms of menopause.

The specific extract used by Flordis

The specific Actaea racemosa extract used by Flordis is known as Ze 450. Ze 450 is extracted and formulated using a specialised process. This individual and highly technical process helps ensure that a consistent form and amount of Ze 450 is used in every formulation - meaning each final product will contain the same high quality active ingredient.

Natural medicines can vary considerably depending on how they are produced. Flordis believes it’s the science behind growing, harvesting and processing that delivers the true health benefits of natural medicine. That’s why in the making of a Flordis medicine, careful attention is applied to plant species and growing methods through to cultivation and harvest, using precise processes to help produce consistent crops. This is continued with extracting and manufacturing of specific ingredients following a series of strict controls to help deliver a consistent medicine from one batch to the next.

It is this specific medicine that is tested in clinical trials and it’s the same medicine that you receive, which is one of the reasons you can feel confident about its effectiveness. Flordis medicines follow processes where all of the steps involved in the growth and manufacture of the natural medicine are tightly controlled to reduce variability and to help ensure consistency.

The Actaea racemosa extract used by Flordis, Ze 450, has been well researched and has demonstrated good results in clinical trials.

Key studies on Ze 450

Clinical trials have demonstrated the Ze 450 extract’s ability to relieve menopausal symptoms:

  • An observational study of 442 women suggested patients who took Ze 450 showed significant improvement of menopausal symptoms1
  • A 12-week, randomized, double-blind, placebo-controlled, 3-armed trial of 180 menopausal women demonstrated that Ze 450 is effective and well-tolerated for relieving menopausal symptoms2

How it works

Scientists still aren’t sure exactly how Actaea racemosa helps to relieve hot flushes and other menopausal symptoms. Some researchers have suggested it plays a role in serotonin and opioid systems as well as possibly other neurotransmitter systems. Research into Actaea racemosa’s specific mechanism of action is ongoing. Scientific studies suggest Ze 450 can effectively relieve the symptoms of menopause without having a phyto-oestrogen like effect. 3,4

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1. Drewe, J. et al. (2013) Phytomedicine, 20:659-666. 2.Schellenberg, R. et al. (2012) Evidence-Based Complementary and Alternative Medicine. doi: 10.1155/2012/260301. 3.Burdette, J.E. et al. (2003) Journal Agric Food Chem, 51(19): 5661-5670. 4.Rhyu, M.R. et al. (2006) Agric Food Chem, 54(26):9852-9857.