For the symptomatic relief of premenstrual syndrome (PMS)

Is Premular right for you? 

For a time each month are you feeling not quite yourself? Perhaps you are less tolerant, angry, and irritable? 

If this happens before your period starts and you’re feeling like your old self again once you begin to menstruate, you may be suffering from Premenstrual Syndrome (PMS). You are not alone.  It is estimated that 40% of women will be significantly affected by PMS symptoms at some time during their life and up to 7% will suffer severe symptoms. The average age of onset is 26 years.1 

The good news is that with Premular there’s something you can do about it. 

Premular is an evidence-based natural medicine that is clinically proven to relieve a range of physical and mental PMS symptoms including irritability, anger, bloating, breast fullness, headache and mood; and provides increasing and sustained relief over time.1-4 Premular is also well tolerated and its once-a-day dosing makes it convenient to take.

The Premular Difference

Premular contains a specific extract of Vitex agnus-castus (Chaste tree), the one that has been used in a number of clinical trials. This extract, referred to as Ze 440, is exclusive to Premular, which means Premular is a Vitex agnus-castus product that has demonstrated significant efficacy in clinical trials, including a double-blind placebo controlled study published in the British Medical Journal.2

One recent publication confirmed that the dose used in Premular is the optimal dose for the relief of PMS symptoms.3

Relief of symptoms: Three published Premular clinical trials suggest significant relief in PMS symptoms for women taking Premular over a 3-month period.2,3 Relief that lasts: Premular can provide increasing and sustained relief over time after 3 cycles.

Premular tablets are easy to take and are well tolerated, with millions of doses recommended worldwide. Premular is manufactured in Switzerland according to proven production methods to help ensure you get a consistently reliable medicine, which is the same medicine used in clinical trials. Premular has also been assigned a ‘well established medicinal use status’ a status based on its history, evidence and excellent tolerability.5,6Learn more about Vitex agnus-castus >

Product details


Premular contains a clinically trialled extract (Ze 440) of the herb Vitex agnus-castus, also known as Chaste tree. Each tablet of Premular contains an extract equivalent to dry Vitex agnus-castus fruit 180mg. Vitex agnus-castus has a long history of traditional use for hormonal conditions and menstrual complaints. Learn more about Vitex agnus-castus.


Available Packaging

30 tablets


Directions for use

Recommended dosage and directions

Adults: 1 tablet per day

For best results take Premular for a minimum of 3 months. 


Premular has a documented safety profile and is well tolerated.


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Is Premular likely to have any side effects?

Premular is generally very well tolerated and not expected to cause unwanted side effects. However, in rare cases occasional itching of the skin may occur and, at the start of the dosage only, certain isolated premenstrual symptoms may be slightly increased. These symptoms should resolve without discontinuing Premular. If you are concerned you are experiencing side effects from Premular, it is important to speak with your healthcare practitioner.

Is Premular likely to interact with any medications?

There are no expected drug interactions with Premular. It is important to discuss taking Premular with a healthcare professional if you are on prescription medications.

Can Premular be used in pregnancy and lactation?

Due to the lack of menstrual cycle during pregnancy, Premular is not indicated for use at this time. Moreover, there are no published studies to establish safety for the use of Premular during pregnancy or while breastfeeding. However, there is also no evidence for concern if a woman taking Premular falls pregnant. It is important to speak with a healthcare professional if you have specific questions or concerns.

Is Premular suitable for children and adolescents?

No, Premular is not recommended for women under the age of 12 years.

How does Premular differ to other chaste tree products?

Premular is clinically proven; it is the exact product that has demonstrated efficacy in clinical trials. This is very important for natural medicines as there can be great variance between products, even if they appear to use the same active ingredients, due to the plant that is used, growing methods, harvesting processes and manufacturing methods. The outcomes of clinical studies for natural medicines may only apply to the exact product that has been examined. 

How long should Premular be taken for?

The minimum recommended treatment period is 3 months, ideally continuing for 6-9 months. Depending on the condition and symptoms, Premular can be continued long term. It is important to speak with a healthcare professional if you have any questions about taking Premular.

When should I start taking Premular in my cycle?

Dosing should be started within the first few days of a menstrual cycle (i.e. within the first few days of menstrual bleeding) and continue throughout the month.

Is Premular gluten free?

Premular has no added gluten.

Does Premular contain lactose?

Yes, Premular contains a very small amount of lactose (40 mg) in each tablet.

Should Premular be stopped before surgery?

It is important to discuss this with your healthcare professional, including anaesthetist and surgeon.

Will Premular affect the ability to drive and operate machinery?

Premular tablets have no known adverse effects in these situations.

Where can I find Premular?

Premular is available at leading pharmacies and selected health shops without a prescription.


1. Lentz, G.M. et al. (2012) Comprehensive Gynecolgy 6th Ed, 36:797-803 2. Schellenberg, R. et al. (2001) BMJ, 322:134-137 3. Schellenberg, R. et al. (2012) Phytomedicine, pii: S0944-7113(12)00280-2 4. Berger, D. et al. (2000) Arch Gynecol Obstet, 264:150-153 5. Committee on Herbal Medicinal Products (HMPC), EMEA/HMPC/144003/2009 6. Committee on Herbal Medicinal Products (HMPC). EMA/HMPC/144006/2009 7. Dickerson, L.M. et al. (2003) Am Fam Phys, 67:1743-52 

Some of this research was conducted using funding provided by Max Zeller Soehne AG, the manufacturer of this product.